Apparently Grand Theft Auto IV in addition to representing Roosevelt Island as Colony Island includes a recreation of the former Smallpox Hospital / Renwick Ruin. According to the "blah-blah-blahg" it is that recreation that is:
"officially my favorite location in the new GTA. they've even replicated ther planks supporting the window bays."
If anyone is able to snag an image of the recreated smallpox hospital or any other locations on "Colony island" I would love to post them here.